Organocatalytic Enantioselective Intramolecular (Hetero)Michael Additions in Desymmetrization Processes

The organocatalytic enantioselective desymmetrization reaction by means of an intramolecular (hetero)Michael addition is a useful strategy for the creation complex carbo- and heterocycles with generation multiple stereocenters in very simple manner. carbon, oxygen nitrogen nucleophiles to prochiral substrates bearing electronically deficient olefins takes place presence organocatalysts, such as chiral primary secondary amines, NHCs, ureas, thioureas, BINOL phosphoric acid derivatives, reaching high levels diastereo- enantioselectivity. main bottleneck this methodology design synthesis starting materials, which compromises its application. To date, majority examples are related use 1,4-cyclohexanedione derivatives.